PhD student position on Molecular mechanisms of muscle lineage reprogramming 


in the group of Dr. Christoph Schaub at the Division of Developmental Biology of the FAU Erlangen-Nürnberg. The position will start at the earliest possible date and will be limited to three years with a possible extension.
The Schaub group is interested in the molecular mechanisms that regulate syncytial muscle cell lineage commitment, maintenance and plasticity using the Drosophila embryonic and adult musculature as a model. The PhD project will focus on the molecular mechanisms that guide a naturally occurring direct lineage reprogramming process during the metamorphosis of the Drosophila musculature. In particular, the project will define the molecular processes that initiate and execute the dedifferentiation of syncytial embryonic muscles into mononucleate myoblasts which in turn are reprogrammed into the progenitors of adult heart associated muscles (Schaub et al. 2015, Curr Biol (25), 488-494). The PhD student will use a broad spectrum of state of the art techniques ranging from genome editing to modern live imaging approaches to analyse these questions.
We are looking for a highly motivated candidate with experience in Drosophila genetics and/or cell and molecular biology. Experience in microscopic tissue dissections is an advantage but not a requirement. We offer an exciting project utilizing our combined expertise in muscle cell biology and Drosophila genetics in a well-equipped lab. The project is embedded in an interdisciplinary scientific landscape in association with the Muscle Research Center Erlangen (MURCE, http://www.murce.fau.de/) and the Optical Imaging Center Erlangen (OICE, http://www.oice.uni-erlangen.de/) and will have access to high end imaging microscopes (Confocal, Spinning disk and Light-sheet microscopy).

If you are interested in the position please send a cover letter stating your motivation, your curriculum vitae, copies of Bachelor/Masters certificate (or equivalent) and two letters of recommendation or contact information for two scientific references in a single PDF to christoph.schaub chez fau.de.