Transcriptomic approaches to identify novel players in the Nodal and BMP signalling pathways during dorsal-ventral and left-right patterning 


We are looking for postdocs and PhD students to work on the role of TGF beta signaling during morphogenesis of the sea urchin embryo. Research in our lab is focused on how morphogens of the TGF beta superfamily such as Nodal and BMPs pattern the dorsal-ventral and left-right axes of the sea urchin embryo (see Molina et al. Nodal : master and commander of the dorsal-ventral and left-right axes in the sea urchin embryo. - 2013 - Curr Opin Genet Dev - 23 P445-53
Lapraz et al. (2015) A deuterostome origin of the Spemann organiser suggested by Nodal and ADMPs functions in Echinoderms. Nature communications and Haillot et al.(2015) The Maternal Maverick/GDF15-like TGF-β Ligand Panda Directs Dorsal-Ventral Axis Formation by Restricting Nodal Expression in the Sea Urchin Embryo. - 2015 - PLoS Biology .)

The project will involve the functional analysis of several novel players of the Nodal signalling pathway that we have identified recently through transcriptomic analysis. The roles and position in the D/V Gene Regulatory Network (GRN) of several novel genes activated specifically in response to Nodal signalling will be analyzed both during dorsal-ventral specification and during left-right patterning. The project will also involve the design and analysis of novel RNA-seq screens to identify genes activated by BMP signalling and genes involved in the initial positioning and growth of the imaginal rudiment.

We seek motivated candidates with a strong interest in Developmental Biology and intercellular signalling and skilled for experimental work. Skills in Bioinformatics will be an additional asset. Further information about the institute can be found at http://ibv.unice.fr/EN/equipe/lepage.php .

Interested candidates should send a Curriculum Vitae, a summary of research interests and goals and contact informations for two or three referees to :
Thierry Lepage
Institut de Biologie Valrose
CNRS UMR7277 – Inserm U1091
Université de Nice Sophia Antipolis
06108 Cedex 2 France
e-mail : tlepage chez unice.fr