Developmental patterning relies on positional cues and cell-cell communication. In the development of Drosophila sensory organs, these are thought to operate in two distinct steps: prepattern factors drive localized expression of proneural genes, then Notch- mediated lateral inhibition singles out neural precursors.
At odds with this paradigm, our recent results (unpublished) reveal a role for self- organization in the emergence of proneural patterns: Notch signaling organizes a sequence of proneural stripes that resolve into regular rows of sensory bristles on the fly thorax. Our goal now is to better characterize the dynamics of this process, and to explore the relevance of self-organized Notch dynamics in other developmental contexts.
The objective of this project is to combine live imaging, optogenetics, and modeling to characterize the dynamics of Notch signaling and neural precursor selection in the Drosophila epidermis. Together with genetic perturbation experiments, this will inform a quantitative description that explicitly connects the molecular scale, cellular dynamics, and the logic of tissue patterning.
This 3-year position is funded by an ANR grant to work as a joint post-doc between the teams of F. Corson (ENS) and F. Schweisguth (Institut Pasteur). The successful candidate will perform image acquisition/analysis and modeling. Applicants should have a strong background in mathematics/physics/modeling and a clear scientific interest for biology. Previous experience in an experimental lab is desirable.
Laboratoire de Physique Statistique Ecole Normale Supérieure
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