Post-doc position in neurodevelopment at the Developmental Biology Institute of Marseille (Marseille, France) 

par  Svetlana

Autism spectrum disorder (ASD) defines a heterogeneous group of neurodevelopmental disorders characterized by impairments in social communication, restricted interests and repetitive behaviors. Recently, we identified the gene TSHZ3 as the minimal region of overlap for 19q12 heterozygous deletions in patients with a new syndrome including autistic features and provided evidence, from studies in mouse models, for a link between heterozygous deletion of Tshz3, defects in cortical projection neurons and ASD-like deficits 1. The goal of the postdoctoral project is to study when, where and how Tshz3 function is critical for the proper development and function of the brain. Different approaches will be used to characterize new conditional Tshz3-knockout mice models, including transcriptomics, and a conditional Tshz3-rescue mouse model to restore Tshz3 function in a spatial- and time-controlled manner will be generated.

This collaborative project between Fasano’s, Habermann’s and Kerkerian-Le Goff teams provides an excellent opportunity for a highly motivated fellow interested in studying the molecular and cellular mechanisms underlying the development and function of neural circuits. Experience in mouse genetics and in molecular neurobiology, neuroanatomy or microscopy is required. Additional knowledge in neurodevelopmental disorders would be a plus. This ANR 2-year funded position (with possible renewal for a 3rd year) is open May 2018.

The team is part of the Developmental Biology Institute of Marseille (IBDM), a research center devoted to understanding development to understand pathologies. The successful candidate will work in a multi-disciplinary environment that brings together neurobiology, electrophysiology, bioinformatics and mouse genetics.

Candidates should apply by sending a CV, a brief outline of current research, scientific interest and career goals, as well as the name of contact details of at least two academic references to laurent.fasano chez univ-amu.fr

1. Caubit, X. et al. TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons. Nature Genetics 48, 1359-1369 (2016).